Phenotypes Associated with This Genotype

Genotype
MGI:3807083

• Allelic Composition: Foxs1^tm1Kmor/Foxs1^tm1Kmor
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6JJcl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Testicular vasculature abnormalities in Foxs1^tm1Kmor/Foxs1^tm1Kmor mice

cardiovascular system

abnormal blood vessel endothelium morphology ( J:138911 )

♂ • mice exhibit gaps in the endothelial lining of the testicular and coelomic vessels

♂ • periendothelial cells exhibit a 3-fold increase in apoptosis rates compared to in wild-type mice

testicular hemorrhage ( J:138911 )

♂ • 33% of mice exhibit accumulation of blood in the central part of the testes

endocrine/exocrine glands

testicular hemorrhage ( J:138911 )

♂ • 33% of mice exhibit accumulation of blood in the central part of the testes

reproductive system

reproductive system phenotype ( J:138911 )

♂N • despite defects in testicular vasculature, male mice exhibit normal fertility

testicular hemorrhage ( J:138911 )

♂ • 33% of mice exhibit accumulation of blood in the central part of the testes