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Phenotypes Associated with This Genotype
Genotype
MGI:3806597
Allelic
Composition		 Kcnk3tm1.1Daba/Kcnk3tm1.1Daba
Kcnk9tm1.1Daba/Kcnk9tm1.1Daba
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnk3tm1.1Daba mutation (0 available); any Kcnk3 mutation (34 available)
Kcnk9tm1.1Daba mutation (0 available); any Kcnk9 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:130850 )
N
• no abnormalities were found in the pH sensitivity of neurons in the retrotrapezoid nucleus
abnormal action potential ( J:130850 )
• serotonergic neurons within the raphe nucleus lack pH dependent-changes in discharge
• wild-type firing rates decrease from 1.2 Hz to 0.5 Hz over a pH range of 6.9 to pH 7.5 while the firing rate of mutant neurons remains constant at about 0.5 Hz over the same pH range
• there are no changes in the averaged I-V relationships obtained during extracellular acidification to alkalization while wild-type neurons rectify weakly and reverse near the expected Ek

respiratory system
respiratory system phenotype ( J:130850 )
N
• whole animal ventilatory response to carbon dioxide is completely retained in this mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory