Phenotypes Associated with This Genotype

Genotype
MGI:3806579

• Allelic Composition: Ntrk2^tm2Kln/Ntrk2^tm2Kln; Tg(Camk2a-cre)159Kln/?
• Genetic Background: involves: 129S2/SvPas * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

impaired synaptic plasticity ( J:130626 )

• basal synaptic transmission is normal but synaptic strengthening is impaired as evidenced by abnormal long term potentiation

abnormal long-term potentiation ( J:130626 )

• there is a reduced induction rate of LTP in hippocampal slices

• induction (measured as a signal 20% above baseline) only occurs 37.0% of the time after burst stimulation compared to 70% in controls

• similar results are observed after tetanus application

• impairment also occurs after long-lasting LTP (L-LTP) that is tested by repeated theta burst

• L-LTP induction rate is 14.2% compared to 62.5% and does not improve with increased stimulus strength