Phenotypes Associated with This Genotype

Genotype
MGI:3806578

• Allelic Composition: Ntrk2^tm1Mini/Ntrk2^tm1Mini
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

impaired synaptic plasticity ( J:130626 )

• basal synaptic transmission is normal but synaptic strengthening is impaired as evidenced by abnormal long term potentiation

abnormal excitatory postsynaptic potential ( J:130626 )

• mean EPSP slope as a percentage of baseline is 125.7% compared to 148.1% in controls

• mean EPSP slope in long-lasting LTP as a percentage of baseline is 116.1% compared to 133.5% in controls

abnormal long-term potentiation ( J:130626 )

• there is a reduced induction rate of LTP in hippocampal slices

• induction (measured as a signal 20% above baseline) only occurs 37.5% of the time after burst stimulation compared to 70% in controls

• similar results are observed after tetanus application

• impairment also occurs after long-lasting LTP (L-LTP) tested by repeated theta burst

• L-LTP induction rate is 30.8% compared to 62.5% and does not improve with increased stimulus strength