Phenotypes Associated with This Genotype

Genotype
MGI:3806502

• Allelic Composition: Tg(H2-L-IL6)46Kish/Tg(H2-L-IL6)46Kish
• Genetic Background: involves: BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased immunoglobulin level ( J:40405 )

• in the F1 backcross mice BALB/c to C57BL/6-Tg(H2-L-IL16)46Kish animals, increase in serum immunoglobulins (at 17 weeks) is accelerated compared to C57BL/6-Tg(H2-L-IL16)46Kish animals (at 20 weeks)

increased IgA level ( J:40405 )

• some mice (3/9) show increase (50- to 200-fold0 in serum IgA at 30 weeks

abnormal immune system organ morphology ( J:40405 )

• infiltration of plasma cells into spleen and bone marrow is observed

abnormal lymph node morphology ( J:40405 )

• lymph nodes are composed of plasma cells by 40 weeks

enlarged mesenteric lymph nodes ( J:40405 )

• at 40 weeks, mesenteric lymph nodes are enlarged

neoplasm

increased plasmacytoma incidence ( J:40405 )

• plasma cells isolated from mice generate plasmacytomas in pristane-treated BALB/c nude mice

homeostasis/metabolism

ascites ( J:40405 )

• mice with elevated IgA develop ascites by 40 weeks

hematopoietic system

increased immunoglobulin level ( J:40405 )

• in the F1 backcross mice BALB/c to C57BL/6-Tg(H2-L-IL16)46Kish animals, increase in serum immunoglobulins (at 17 weeks) is accelerated compared to C57BL/6-Tg(H2-L-IL16)46Kish animals (at 20 weeks)

increased IgA level ( J:40405 )

• some mice (3/9) show increase (50- to 200-fold0 in serum IgA at 30 weeks