Phenotypes Associated with This Genotype

Genotype
MGI:3806501

• Allelic Composition: Tg(H2-L-IL6)46Kish/Tg(H2-L-IL6)46Kish
• Genetic Background: C57BL/6-Tg(H2-L-IL6)46Kish

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:40405 )

hematopoietic system

increased plasma cell number ( J:40405 )

• fatal plasmacytosis is observed

increased immunoglobulin level ( J:40405 )

• polyclonal increase in serum immunoglobulins is detected by 20 weeks

immune system

increased plasma cell number ( J:40405 )

• fatal plasmacytosis is observed

increased immunoglobulin level ( J:40405 )

• polyclonal increase in serum immunoglobulins is detected by 20 weeks

enlarged mesenteric lymph nodes ( J:40405 )

• enlarged at 40 weeks

enlarged axillary lymph nodes ( J:40405 )

• enlarged at 40 weeks

glomerulonephritis ( J:40405 )

• mice exhibit mesangial proliferative glomerulonephritis

neoplasm

increased plasmacytoma incidence ( J:40405 )

renal/urinary system

glomerulonephritis ( J:40405 )

• mice exhibit mesangial proliferative glomerulonephritis