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Phenotypes Associated with This Genotype
Genotype
MGI:3806464
Allelic
Composition
Robo1tm1Phr/Robo1+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Robo1tm1Phr mutation (0 available); any Robo1 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• spontaneously develop lung lymphomas and carcinomas during the second year of life with a 3-fold increase in incidence compared with controls (J:93666)
• spontaneously develop lung lymphomas and carcinomas during the second year of life with a 3-fold increase in incidence compared with controls (J:93666)
• spontaneously develop lung lymphomas and carcinomas during the second year of life with a 3-fold increase in incidence compared with controls (J:93666)
• spontaneously develop lung lymphomas and carcinomas during the second year of life with a 3-fold increase in incidence compared with controls (J:93666)
• 26.5% of tumors that develop in heterozygotes are lung adenocarcinomas (J:93666)
• 26.5% of tumors that develop in heterozygotes are lung adenocarcinomas (J:93666)

Mouse Models of Human Disease
OMIM ID Ref(s)
Lung Cancer 211980 J:93666


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory