Phenotypes Associated with This Genotype

Genotype
MGI:3806316

• Allelic Composition: Tg(RHO-VEGFA)V-6Camp/0
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

retina neovascularization ( J:41411 , J:138010 )

• focal areas of intraretinal and subretinal neovascularization are seen at 1 month of age (J:41411)

• blood vessels extend from the inner nuclear layer through the outer nuclear layer and form small networks of vessels in the outer segment layer (J:41411)

• at 3 months of age, vessels extend down from the inner nuclear layer to form a large plexus of vessels in the subretinal space (J:41411)

• in some cases vessel lumens and cavities within the plexus contain retinal pigment epithelial cells (J:41411)

increased vascular permeability ( J:41411 )

• at 1, 3, and 4 months of age leakage is detected in the retinal vasculature

vision/eye

retina neovascularization ( J:41411 , J:138010 )

• focal areas of intraretinal and subretinal neovascularization are seen at 1 month of age (J:41411)

• blood vessels extend from the inner nuclear layer through the outer nuclear layer and form small networks of vessels in the outer segment layer (J:41411)

• at 3 months of age, vessels extend down from the inner nuclear layer to form a large plexus of vessels in the subretinal space (J:41411)

• in some cases vessel lumens and cavities within the plexus contain retinal pigment epithelial cells (J:41411)

abnormal retina pigment epithelium morphology ( J:41411 )

• proliferating retinal pigment epithelial cells are found around some site of neovascularization

• some cells around the neovascularization sites contain large cavities

pigmentation

abnormal retina pigment epithelium morphology ( J:41411 )

• proliferating retinal pigment epithelial cells are found around some site of neovascularization

• some cells around the neovascularization sites contain large cavities