Phenotypes Associated with This Genotype

Genotype
MGI:3806273

• Allelic Composition: Tg(Pdx1-Ffar1)AHeed/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased insulin secretion ( J:129843 )

• mice have a loss of first-phase insulin release and a severely blunted second-phase insulin release during tolerance tests

impaired glucose tolerance ( J:129843 )

• mice are glucose intolerant with blood glucose levels being significantly higher and remaining high longer than in non-transgenic controls

endocrine/exocrine glands

disorganized pancreatic islets ( J:129843 )

• the alpha cells are distributed throughout the islets instead of on the periphery

abnormal pancreatic beta cell physiology ( J:129843 )

• total insulin content in the pancreas is about half that of wild-type pancreas while gene transcript levels for insulin are normal

decreased insulin secretion ( J:129843 )

• mice have a loss of first-phase insulin release and a severely blunted second-phase insulin release during tolerance tests