Phenotypes Associated with This Genotype

Genotype
MGI:3806160

• Allelic Composition: Nr1h4^tm1Gonz/Nr1h4^tm1Gonz
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

abnormal bile composition ( J:129978 )

• the increase in the bile acid pool consists of increases in cholate and its derivates including taurocholic acid and taurodeoxycholic acid while other bile acids are found at normal levels

homeostasis/metabolism

increased circulating cholesterol level ( J:129978 )

• total cholesterol levels in serum are about double that found in wild-type mice

increased circulating triglyceride level ( J:129978 )

• serum triglyceride levels are significantly higher than in control mice

increased bile salt level ( J:129978 )

• serum bile acids are greatly elevated in these mice

• total bile acid pool collected from liver, gallbladder and small intestine is almost 2.5-fold higher than in controls

• the increases in the bile acid pool consist of increases in cholate and its derivates including taurocholic acid and taurodeoxycholic acid