Phenotypes Associated with This Genotype

Genotype
MGI:3806151

• Allelic Composition: C3^tm1Crr/C3^tm1Crr
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal blood coagulation ( J:44715 )

• thrombus formation considerably reduced

decreased urine albumin level ( J:44715 )

• albuminuria 1/50 control levels after 0.5ng dose of anti glomerular basement membrane antiserum and 1/13 of control levels after 1 ng of antiserum

decreased susceptibility to injury ( J:128218 )

• following exposure to ethanol, mice do not develop microvesicular or macrovesicular steatosis of the liver and do not accumulate excessive trglycerides as in wild-type mice

• following exposure to ethanol, mice exhibit a reduced increased in alanine aminotransferase compared to in similarly treated wild-type mice

liver/biliary system

decreased susceptibility to alcohol-induced hepatic steatosis ( J:128218 )

• following exposure to ethanol, mice do not develop microvesicular or macrovesicular steatosis of the liver

renal/urinary system

decreased urine albumin level ( J:44715 )

• albuminuria 1/50 control levels after 0.5ng dose of anti glomerular basement membrane antiserum and 1/13 of control levels after 1 ng of antiserum

glomerulonephritis ( J:44715 )

• reduced neutrophil infiltration of glomerulus relative to controls when injected with 0.5 mg but not with 1.0mg of anti-glomerular basement membrane antiserum

immune system

glomerulonephritis ( J:44715 )

• reduced neutrophil infiltration of glomerulus relative to controls when injected with 0.5 mg but not with 1.0mg of anti-glomerular basement membrane antiserum