Phenotypes Associated with This Genotype

Genotype
MGI:3806109

• Allelic Composition: Igh-8^{tm2(Ighg1)Aak}/Igh-8^{tm2(Ighg1)Aak}
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal class switch recombination ( J:130574 )

• class switch to the gamma3 constant region is abrogated both in vivo and in vitro despite reduced levels of germline mRNA transcripts of gamma3 being detectable in B cells

decreased IgG3 level ( J:130574 )

• non-immunized mice have no IgG3 in their sera

• splenocytes cultured in vitro with LPS do not have IgG3 on their cell surface or secrete it into the media in contrast to splenocytes from control mice that produce IgG3 in the presence of LPS

hematopoietic system

abnormal class switch recombination ( J:130574 )

• class switch to the gamma3 constant region is abrogated both in vivo and in vitro despite reduced levels of germline mRNA transcripts of gamma3 being detectable in B cells

decreased IgG3 level ( J:130574 )

• non-immunized mice have no IgG3 in their sera

• splenocytes cultured in vitro with LPS do not have IgG3 on their cell surface or secrete it into the media in contrast to splenocytes from control mice that produce IgG3 in the presence of LPS