Phenotypes Associated with This Genotype

Genotype
MGI:3806032

• Allelic Composition: L1cam^tm1Sor/Y; Nrcam^tm1Gmt/Nrcam^tm1Gmt
• Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Swiss Webster

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cerebellar abnormalities in L1cam^tm1Sor/Y Nrcam^tm1Gmt/Nrcam^tm1Gmt mice

mortality/aging

postnatal lethality ( J:71828 )

♂ • do not detect any mutants at P8

growth/size/body

decreased body weight ( J:71828 )

♂ • body weights of pups are 40-70% of control littermates at P3-P6

nervous system

abnormal cerebellum development ( J:71828 )

♂ • cerebellar dysgenesis

♂ • cerebellar fissures are less developed

♂ • thickness of the inner granule layer is reduced by 40-50%

abnormal cerebellar foliation ( J:71828 )

♂ • marker analysis indicates defects in foliation

abnormal cerebellum external granule cell layer morphology ( J:71828 )

♂ • thickness of the external granule layer is reduced by 10-30%

abnormal cerebellar cortex morphology ( J:71828 )

♂ • cerebellar lobes are less developed

abnormal cerebellar granule layer morphology ( J:71828 )

♂ • marker analysis indicates possible defects in granule cells during cerebellar development

♂ • thickness of the inner granule layer is reduced by 40-50%

♂ • thickness of the external granule layer is reduced by 10-30%

small cerebellum ( J:71828 )

♂