Phenotypes Associated with This Genotype

Genotype
MGI:3806021

• Allelic Composition: Fzr1^{Gt(RRJ067)Byg}/Fzr1^{Gt(RRJ067)Byg}
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:138545 )

• no embryos survive beyond E9.5

growth/size/body

embryonic growth retardation ( J:138545 )

• developmentally delayed by about 1 day at E9.5

decreased embryo size ( J:138545 )

• much smaller in size at E9.5 than controls

embryo

embryonic growth retardation ( J:138545 )

• developmentally delayed by about 1 day at E9.5

decreased embryo size ( J:138545 )

• much smaller in size at E9.5 than controls

abnormal placenta morphology ( J:138545 )

absent trophoblast giant cells ( J:138545 )

small placenta ( J:138545 )

• smaller and thinner than controls at E9.5

cellular

binucleate ( J:138545 )

• about 12% of MEFs in culture are binucleate

abnormal mitosis ( J:138545 )

• small increase in the number of telophase cells

• mitosis is otherwise normal

decreased cell proliferation ( J:138545 )

• MEF growth is slower in culture

• MEF growth in culture ceases after passage 6