Phenotypes Associated with This Genotype

Genotype
MGI:3805820

• Allelic Composition: Bmi1^{tm1(cre/ERT)Mrc}/Bmi1⁺; Gt(ROSA)26Sor^tm1(DTA)Mrc/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:138364 )

• mice die 2 to 3 days following administration of tamoxifen for three consecutive days after weaning

digestive/alimentary system

abnormal duodenum crypts of Lieberkuhn morphology ( J:138364 )

• following administration of one dose of tamoxifen after weaning, mice exhibit areas of the duodenum that are devoid of crypt cells

• however, crypt cells recover by 9 months of age

abnormal jejunum crypts of Lieberkuhn morphology ( J:138364 )

• following administration of one dose of tamoxifen after weaning, mice exhibit areas of the jejunum that are devoid of crypt cells

• however, crypt cells recover by 9 months of age

growth/size/body

slow postnatal weight gain ( J:138364 )

• following administration of one dose of tamoxifen after weaning

• however, normal weight is recovered by 9 months of age

endocrine/exocrine glands

abnormal duodenum crypts of Lieberkuhn morphology ( J:138364 )

• following administration of one dose of tamoxifen after weaning, mice exhibit areas of the duodenum that are devoid of crypt cells

• however, crypt cells recover by 9 months of age

abnormal jejunum crypts of Lieberkuhn morphology ( J:138364 )

• following administration of one dose of tamoxifen after weaning, mice exhibit areas of the jejunum that are devoid of crypt cells

• however, crypt cells recover by 9 months of age