About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3805720
Allelic
Composition
Gp1bbtm1Frla/Gp1bbtm1Frla
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gp1bbtm1Frla mutation (1 available); any Gp1bb mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• discoid platelets have enlarged diameter compared to wild-type
• platelets display 2-fold increase in number of microtubules
• platelet counts are reduced by 73%

homeostasis/metabolism
• platelet adhesion from blood at high shear forces (3000 s-1) is nearly abolished (98% decrease) relative to wild-type blood; platelet adhesion and aggregation is observed at greatly reduced size compared to wild-type at a shear rate of 1500 s-1
• in vivo, application of FeCl3 produces stable occlusion in 12.5% of arteries, while 25% show unstable occlusions and 62.5% do not occlude after 30 minutes compared to 75% in wild-type; thrombi are less extensive than wild-type with little sign of degranulation
• laser beam-induced superficial lesions of mesenteric arterioles results in almost no thrombus formation compared to wild-type while thrombi after severe lesions are reduced to only 25% of wild-type at 160 seconds
• 76% of mice bled for more than 20 minutes compared to 82% of wild-type having bleeding times of <12 minutes

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Bernard-Soulier syndrome DOID:2217 OMIM:231200
J:135065


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory