Phenotypes Associated with This Genotype

Genotype
MGI:3805579

• Allelic Composition: Tg(Gfap-Il6)G16Lms/0; Tg(Gfap-lacZ)1Lms/0
• Genetic Background: involves: C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:125549 )

• mice die between 3 and 10 weeks of age

behavior/neurological

abnormal pilomotor reflex ( J:125549 )

tremors ( J:125549 )

ataxia ( J:125549 )

hunched posture ( J:125549 )

paraparesis ( J:125549 )

• hindlimb weakness

seizures ( J:125549 )

nervous system

seizures ( J:125549 )

astrocytosis ( J:125549 )

• mild

abnormal cerebellar molecular layer ( J:125549 )

• mice exhibit condensation of the molecular layer

immune system

immune system phenotype ( J:125549 )

N • despite neuronal damage mice do not exhibit encephalitis or meningitis

growth/size/body

decreased body size ( J:125549 )

• at 1 to 2 weeks of age

cardiovascular system

vascular inflammation ( J:125549 )

• mice exhibit discrete perivasculitis in a small number of larger blood vessels in the cerebellar sulci

integument

ruffled hair ( J:125549 )

cellular

astrocytosis ( J:125549 )

• mild