Phenotypes Associated with This Genotype

Genotype
MGI:3805578

• Allelic Composition: Tg(Gfap-Il6)G167Lms/0
• Genetic Background: involves: C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:125549 )

• mice die between 3 and 10 weeks of age

behavior/neurological

abnormal pilomotor reflex ( J:125549 )

tremors ( J:125549 )

• by 6 months of age

ataxia ( J:125549 )

• by 6 months of age

hunched posture ( J:125549 )

paraparesis ( J:125549 )

• hindlimb weakness

seizures ( J:125549 )

nervous system

seizures ( J:125549 )

astrocytosis ( J:125549 )

• mild

cardiovascular system

abnormal physiological neovascularization ( J:125549 )

• mice exhibit moderate neovascularization in the cerebellum

• at 6 months of age, mice exhibit proliferative angiopathy in the cerebellum

growth/size/body

decreased body size ( J:125549 )

• at 1 to 2 weeks of age

cellular

astrocytosis ( J:125549 )

• mild