Phenotypes Associated with This Genotype

Genotype
MGI:3805329

• Allelic Composition: Rybp^tm1Nisa/Rybp⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

optic nerve atrophy ( J:134428 )

• the optic nerve is frequently regressed in the retinas of E14.5 embryos

ventral rotation of lens ( J:134428 )

• lenses are ventrally rotated and misplaced within the eyeball in E14.5 embryos with coloboma

coloboma ( J:134428 )

• 32% of E14.5 embryos that are exencephalic also have retinal/optic nerve coloboma

• the colobomas occur both bilaterally and unilaterally and result from incomplete closure of the optic fissure

optic nerve coloboma ( J:134428 )

retina coloboma ( J:134428 )

retina hyperplasia ( J:134428 )

• the neuroretina is thickened in E14.5 embryos with coloboma

nervous system

optic nerve coloboma ( J:134428 )

optic nerve atrophy ( J:134428 )

• the optic nerve is frequently regressed in the retinas of E14.5 embryos