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Phenotypes Associated with This Genotype
Genotype
MGI:3805313
Allelic
Composition		 Ezh2tm1.1Sho/Ezh2tm1.1Sho
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ezh2tm1.1Sho mutation (0 available); any Ezh2 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:134477 )
• developmental arrest and gastrulation failure at day 6.5

embryo
failure to gastrulate ( J:134477 )
• gastrulation failure at day 6.5
embryonic growth arrest ( J:134477 )
• developmental arrest at day 6.5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory