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Phenotypes Associated with This Genotype
Genotype
MGI:3805209
Allelic
Composition
Rybptm1Nisa/Rybp+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rybptm1Nisa mutation (0 available); any Rybp mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 15% of mice die at birth from exencephaly

nervous system
• some E10 embryos have neural tubes with openings at the forebrain/midbrain boundary
• forebrain overgrowth in the 15% of mice that have exencephaly
• disorganization and the absence of parts of the mid-brain are noted in the 15% of mice born with exencephaly
• 15% of mice are born with exencephaly
• excencephaly results from forebrain overgrowth and ventricular stenosis

embryo
• some E10 embryos have neural tubes with openings at the forebrain/midbrain boundary


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory