Phenotypes Associated with This Genotype

Genotype
MGI:3805208

• Allelic Composition: Rybp^tm1Nisa/Rybp^tm1Nisa
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:134591 )

• lethality occurs between E3.5 and E7.5 with abnormalities in embryo development first occurring at E4.5

growth/size/body

embryonic growth retardation ( J:134591 )

• E5.5 embryos are retarded in growth development and patterning

• the number of E5.5 embryonic cells proliferating are dramatically reduced

• E3.5 blastocytes cultured in vitro fail to survive

embryo

embryonic growth retardation ( J:134591 )

• E5.5 embryos are retarded in growth development and patterning

• the number of E5.5 embryonic cells proliferating are dramatically reduced

• E3.5 blastocytes cultured in vitro fail to survive

abnormal embryonic epiblast morphology ( J:134591 )

• E5.5 embryos have a disorganized presumptive epiblast with cellular degeneration

embryonic epiblast cell degeneration ( J:134591 )

• E5.5 embryos have a disorganized presumptive epiblast with cellular degeneration

absent trophoblast giant cells ( J:134591 )

• trophoblast giant cells are completely absent in E6.0 embryos

absent trophectoderm ( J:134591 )

• E3.5 blastocytes cultured in vitro fail to form trophectodermal outgrowths

abnormal visceral endoderm morphology ( J:134591 )

• the presumptive visceral endoderm has extensive vacuolization at E6.0

reproductive system

impaired embryo implantation ( J:134591 )

♀ • mutant embryos begin to implant but are unable to trigger apoptosis in the underlying endometrium