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Phenotypes Associated with This Genotype
involves: 129S/SvEv * 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm1Arge mutation (0 available); any Brca1 mutation (44 available)
Brca1tm1Thl mutation (0 available); any Brca1 mutation (44 available)
Waptm1(cre)Arge mutation (0 available); any Wap mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 512 days
• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive
• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate
• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes
• neoplasms often invade in a broad front and push towards the underlying pectoral muscle
• a small minority of tumors have sqaumous characteristics
• pre-cancerous neoplasia are also evident throughout the mammary gland

Mouse Models of Human Disease
OMIM ID Ref(s)
Breast Cancer 114480 J:134977

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory