Mouse Genome Informatics

involves: 129S/SvEv * 129S1/Sv * C57BL/6J
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
• almost all female mice who have been pregnant at least once develop mammary tumors with a mean tumor free latency of 512 days
• majority of tumors are solid, do not express the estrogen receptor but are CK14 positive
• the majority of the tumors are Dunn type B adenocarcinomas with a medullary growth pattern that display variable necrosis and lack peripheral lymphocytic infiltrate
• carnicomas contain pleomorphic cells with numerous mitotic figures such as lagging chromosomes
• neoplasms often invade in a broad front and push towards the underlying pectoral muscle
• a small minority of tumors have sqaumous characteristics
• pre-cancerous neoplasia are also evident throughout the mammary gland

Mouse Models of Human Disease
Breast Cancer 114480 J:134977