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Phenotypes Associated with This Genotype
Genotype
MGI:3804820
Allelic
Composition		 Cd200r1tm1.1Rmgo/Cd200r1tm1.1Rmgo
Tg(tetO/CMV-CD200)1Rmgo/Tg(tetO/CMV-CD200)1Rmgo
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd200r1tm1.1Rmgo mutation (0 available); any Cd200r1 mutation (33 available)
Tg(tetO/CMV-CD200)1Rmgo mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal dendritic cell physiology ( J:134313 )
• bone marrow derived dendritic cells from mice given doxycycline for 2 weeks are polarized to induce antigen specific T regulatory cells in vitro
• 4 x 106 dendritic cells isolated from mutant mice are able to significantly prolong allogenic skin graft survival when transferred to C57BL/6 hosts
• these tolerogenic dendritic cells no longer suppress skin graft rejection if host mice are injected with neutralizing antibodies to TGF-beta1 and IL-10 at the same time as receiving dendritic cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory