Phenotypes Associated with This Genotype

Genotype
MGI:3804665

• Allelic Composition: Tbx6^tm1Pa/Tbx6^tm2Pa
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal motile primary cilium morphology ( J:137163 )

• some cilia are shorter and thicker

• most cilia have terminal bulges or balloon like structures

abnormal direction of embryo turning ( J:137163 )

• direction of turning is completely reversed in 18% (7 of 38) of embryos and partially reversed in an additional 4 embryos

• embryos with reversal of turning direction do not always also have reversal of the direction of heart looping

cardiovascular system

abnormal direction of heart looping ( J:137163 )

• at E9.5 - E10.5, about 40% of embryos show either completely reversed or ventral rather than horizontal looping

cellular

abnormal motile primary cilium morphology ( J:137163 )

• some cilia are shorter and thicker

• most cilia have terminal bulges or balloon like structures