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Phenotypes Associated with This Genotype
Genotype
MGI:3804635
Allelic
Composition
Rpsatm1Ells/Rpsa+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rpsatm1Ells mutation (1 available); any Rpsa mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• mice exhibit prenatal growth retardation (weight is lower than wild-type littermates at E14.5); differences normalize postnatally

craniofacial
• some heterogeneous defects (skull defects, anophthalmia) are observed on mixed 129/B6 background (in about a third of the F2 generation mice), but are no longer observed when animals are backcrossed 4 or more generations onto a C57BL/6 background

endocrine/exocrine glands
• cells have slightly decreased insulin content
• however, mutants display normal glucose tolerance, insulin sensitivity and insulin secretion

hematopoietic system
• MCH is significantly lower after treatment with Fluorouracil (a myelosuppressor) compared to wild-type animals


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory