Phenotypes Associated with This Genotype

Genotype
MGI:3804626

• Allelic Composition: Asgr1^tm1Sau/Asgr1^tm1Sau
• Genetic Background: B6.129S4-Asgr1^tm1Sau

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:136946 )

• following infection with S. pneumoniae, mice exhibit decreased survival compared to similarly treated wild-type mice

homeostasis/metabolism

decreased bleeding time ( J:136946 )

immune system

increased susceptibility to bacterial infection ( J:136946 )

• following infection with S. pneumoniae, mice exhibit decreased survival compared to similarly treated wild-type mice

• following infection with S. pneumoniae, mice exhibit hemorrhage of the spleen, increased hepatocyte cell death, and increased vascular occlusion and fibrin deposition in the kidney and liver compared to similarly treated wild-type mice