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Phenotypes Associated with This Genotype
Genotype
MGI:3804428
Allelic
Composition		 En1tm2(cre)Wrst/?
Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym/?
Nkx2-2tm1Jlr/Nkx2-2tm1Jlr
Tg(Fev-flpe)1Dym/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1tm2(cre)Wrst mutation (1 available); any En1 mutation (34 available)
Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym mutation (0 available); any Gt(ROSA)26Sor mutation (1098 available)
Nkx2-2tm1Jlr mutation (0 available); any Nkx2-2 mutation (16 available)
Tg(Fev-flpe)1Dym mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal rhombomere morphology ( J:136096 )
• alleles are used in intersectional and subtractive cell lineage fate mapping to visualize serotonin (5-HT) producing neurons and their precursors in the P0.5 brainstem
• rhombomere-1 (r1) derived 5-HT precursor cells are not found in the B1-B3 areas of the brainstem

embryo
abnormal rhombomere morphology ( J:136096 )
• alleles are used in intersectional and subtractive cell lineage fate mapping to visualize serotonin (5-HT) producing neurons and their precursors in the P0.5 brainstem
• rhombomere-1 (r1) derived 5-HT precursor cells are not found in the B1-B3 areas of the brainstem

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/31/2026
MGI 6.24 		The Jackson Laboratory