Phenotypes Associated with This Genotype

Genotype
MGI:3804310

• Allelic Composition: Pdpk1^tm1Jcbr/Pdpk1^tm1Jcbr; Tg(Pomc1-cre)16Lowl/0
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body weight ( J:134336 )

• males and females fed either a normal chow diet or a high-fat chow diet display slightly but significantly increased body weight, although over time, weight normalizes

• corticosterone replacement in mutants increases food intake and body weight

homeostasis/metabolism

decreased circulating corticosterone level ( J:134336 )

• reduction in plasma corticosterone concentrations is seen as early as 3 weeks of age, with levels continuing to decrease over time

• mutants show an impairment in stress-induced corticosterone production

• injection of ACTH analog does not increase plasma corticosterone to the level of control mice, consistent with adrenal insufficiency

• corticosterone replacement in mutants increases food intake and body weight

abnormal circulating leptin level ( J:134336 )

• initially, mutants exhibit an elevation in serum leptin levels at 8 weeks of age, however by 18 weeks of age, they show lower serum leptin levels than controls but have an unchanged body weight

abnormal glucose homeostasis ( J:134336 )

decreased insulin secretion ( J:134336 )

• glucose-stimulated insulin secretion is lower than in controls

decreased circulating glucose level ( J:134336 )

• analysis of glucose-stimulated insulin secretion shows that although insulin secretion is lower, their blood glucose concentration is also lower than in controls

increased circulating glucose level ( J:134336 )

• initial elevation in serum glucose levels at 8 weeks of age

improved glucose tolerance ( J:134336 )

• old mutants perform better than controls during glucose tolerance tests

increased insulin sensitivity ( J:134336 )

• old mutants show significantly increased insulin sensitivity during insulin tolerance tests than controls

endocrine/exocrine glands

decreased corticotroph cell number ( J:134336 )

abnormal melanotroph morphology ( J:134336 )

• decrease in melanotroph numbers in the intermediate lobe of the pituitary, but do not see an obvious change in fur color or skin pigmentation

decreased insulin secretion ( J:134336 )

• glucose-stimulated insulin secretion is lower than in controls

adipose tissue

decreased gonadal fat pad weight ( J:134336 )

• at 18 weeks of age, mutants show reduced epigonadal fat-pad mass

behavior/neurological

polyphagia ( J:134336 )

• significant hyperphagia at 8 weeks of age but not at 10 weeks of age

• corticosterone replacement in mutants increases food intake and body weight

nervous system

decreased corticotroph cell number ( J:134336 )

abnormal melanotroph morphology ( J:134336 )

• decrease in melanotroph numbers in the intermediate lobe of the pituitary, but do not see an obvious change in fur color or skin pigmentation