Phenotypes Associated with This Genotype

Genotype
MGI:3804256

• Allelic Composition: Ddx20^tm1Yosa/Ddx20⁺
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal ovarian follicle morphology ( J:136021 )

♀ • about 25% of follicles are devoid of oocytes, which is significantly higher than in wild-type females (about 5%)

♀ • empty follicles are found at every stage of maturation

increased ovary weight ( J:136021 )

♀ • ovaries are about 50% heavier than in wild-type controls

♀ • there is no significant differences in weight of testes or adrenal glands

homeostasis/metabolism

decreased circulating adrenocorticotropin level ( J:136021 )

• females have significantly less serum levels of ACTH in evenings and after 30 minutes of restraint stress compared to female controls

reproductive system

abnormal ovarian follicle morphology ( J:136021 )

♀ • about 25% of follicles are devoid of oocytes, which is significantly higher than in wild-type females (about 5%)

♀ • empty follicles are found at every stage of maturation

increased ovary weight ( J:136021 )

♀ • ovaries are about 50% heavier than in wild-type controls

♀ • there is no significant differences in weight of testes or adrenal glands

abnormal estrous cycle ( J:136021 )

♀

prolonged estrus ( J:136021 )

♀ • females spend more time in estrous (42%) than do female controls (27%)

growth/size/body

increased ovary weight ( J:136021 )

♀ • ovaries are about 50% heavier than in wild-type controls

♀ • there is no significant differences in weight of testes or adrenal glands