Phenotypes Associated with This Genotype

Genotype
MGI:3804202

• Allelic Composition: Tcf3^tm1Mbu/Tcf3^tm1.2Mbu; Tg(Aicda-cre)9Mbu/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:137719 )

N • despite reduced B cell numbers, class switching and B cell proliferation following stimulation are normal following immunization

decreased B cell number ( J:137719 )

• following immunization, the number of IgG2a- and IgG3-secreting cells is decreased compared to in wild-type mice

abnormal germinal center B cell morphology ( J:137719 )

• 8 days following immunization, PNA+ germinal center number and size are reduced compared to in wild-type or heterozygous mice

• however, stimulated germinal B cell proliferation is normal

decreased germinal center B cell number ( J:137719 )

• at day 4 following immunization, the number of germinal cell B cells in the spleen is reduced and remains 7- to 4-fold lower at day 8 and 12 compared to in wild-type and heterozygous mice

hematopoietic system

decreased B cell number ( J:137719 )

• following immunization, the number of IgG2a- and IgG3-secreting cells is decreased compared to in wild-type mice

decreased germinal center B cell number ( J:137719 )

• at day 4 following immunization, the number of germinal cell B cells in the spleen is reduced and remains 7- to 4-fold lower at day 8 and 12 compared to in wild-type and heterozygous mice

abnormal germinal center B cell morphology ( J:137719 )

• 8 days following immunization, PNA+ germinal center number and size are reduced compared to in wild-type or heterozygous mice

• however, stimulated germinal B cell proliferation is normal