Phenotypes Associated with This Genotype

Genotype
MGI:3804199

• Allelic Composition: Tcf3^tm1Mbu/Tcf3^tm1.2Mbu; Tg(Fcer2a-cre)5Mbu/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:137719 )

N • despite reduced B cell numbers, class switching, NP-specific production of IgG1, IgG2a and IgG3, B cell proliferation, memory B cells and plasma B cells following stimulation are normal following immunization

increased marginal zone B cell number ( J:137719 )

• slight

decreased B cell number ( J:137719 )

• splenic B cell numbers are minimally reduced compared to in wild-type mice

abnormal germinal center B cell morphology ( J:137719 )

• 8 days following immunization, PNA+ germinal center number and size are reduced compared to in wild-type or heterozygous mice

• however, stimulated germinal B cell proliferation is normal

decreased germinal center B cell number ( J:137719 )

• at 4 and 8 days after immunization germinal center B cell numbers are 3- to 5-fold lower tan in wild-type or heterozygous mice

hematopoietic system

increased marginal zone B cell number ( J:137719 )

• slight

decreased B cell number ( J:137719 )

• splenic B cell numbers are minimally reduced compared to in wild-type mice

decreased germinal center B cell number ( J:137719 )

• at 4 and 8 days after immunization germinal center B cell numbers are 3- to 5-fold lower tan in wild-type or heterozygous mice

abnormal germinal center B cell morphology ( J:137719 )

• 8 days following immunization, PNA+ germinal center number and size are reduced compared to in wild-type or heterozygous mice

• however, stimulated germinal B cell proliferation is normal