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Phenotypes Associated with This Genotype
Genotype
MGI:3804179
Allelic
Composition		 Itgb4tm1Mfel/Itgb4tm1Mfel
Tg(Mpz-cre)26Mes/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb4tm1Mfel mutation (0 available); any Itgb4 mutation (109 available)
Tg(Mpz-cre)26Mes mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal myelin sheath morphology ( J:137852 )
• progressive increase in the number of myelin infoldings in the sciatic nerve, digital nerve, and anterior roots after 12 months of age

behavior/neurological
behavior/neurological phenotype ( J:137852 )
N
• despite loss of expression in Schwann cells, no tremors, gait abnormalities, or motor skill impairments are detected

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory