Phenotypes Associated with This Genotype

Genotype
MGI:3804005

• Allelic Composition: Akt1^Gt1Pnt/Akt1^Gt1Pnt; Tg(MMTV-Erbb2)NK1Mul/Tg(MMTV-Erbb2)NK1Mul
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:117336 )

• 10% of female virgin mice develop mammary tumors by 60 weeks of age which is a much lower incidence than occurs in mice carrying the transgene on a wild-type background

• tumor growth in mammary glands is significantly slower than is found in transgenic mice on a wild-type background

• intravascular metastasis of adenocarcinomas into the lung is slightly enhanced in these mice

integument

increased mammary adenocarcinoma incidence ( J:117336 )

• 10% of female virgin mice develop mammary tumors by 60 weeks of age which is a much lower incidence than occurs in mice carrying the transgene on a wild-type background

• tumor growth in mammary glands is significantly slower than is found in transgenic mice on a wild-type background

• intravascular metastasis of adenocarcinomas into the lung is slightly enhanced in these mice

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:117336 )

• 10% of female virgin mice develop mammary tumors by 60 weeks of age which is a much lower incidence than occurs in mice carrying the transgene on a wild-type background

• tumor growth in mammary glands is significantly slower than is found in transgenic mice on a wild-type background

• intravascular metastasis of adenocarcinomas into the lung is slightly enhanced in these mice