Phenotypes Associated with This Genotype

Genotype
MGI:3804004

• Allelic Composition: Akt2^tm1.1Mbb/Akt2^tm1.1Mbb; Tg(MMTV-Erbb2)NK1Mul/Tg(MMTV-Erbb2)NK1Mul
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:117336 )

• female virgin mice develop mammary tumors by 45 weeks of age which is significantly earlier than occurs in mice carrying the transgene on a wild-type background

• intravascular metastasis of adenocarcinomas into the lung occurs in some mice

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:117336 )

• female virgin mice develop mammary tumors by 45 weeks of age which is significantly earlier than occurs in mice carrying the transgene on a wild-type background

• intravascular metastasis of adenocarcinomas into the lung occurs in some mice

integument

increased mammary adenocarcinoma incidence ( J:117336 )

• female virgin mice develop mammary tumors by 45 weeks of age which is significantly earlier than occurs in mice carrying the transgene on a wild-type background

• intravascular metastasis of adenocarcinomas into the lung occurs in some mice