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Phenotypes Associated with This Genotype
Genotype
MGI:3803976
Allelic
Composition		 Tcratm1Mom/Tcratm1Mom
Tg(Lck-Akt1*E40K)E-3Pnt/0
Genetic
Background		 involves: 129S2/SvPas * C3H/He * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcratm1Mom mutation (8 available); any Tcra mutation (102 available)
Tg(Lck-Akt1*E40K)E-3Pnt mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
arrested T cell differentiation ( J:135903 )
• T cell development is arrested at the double positive stage
• the presence of the transgene does not overcome this block the presence of the transgene does not overcome this block the presence of the transgene does not overcome this block

hematopoietic system
arrested T cell differentiation ( J:135903 )
• T cell development is arrested at the double positive stage
• the presence of the transgene does not overcome this block the presence of the transgene does not overcome this block the presence of the transgene does not overcome this block

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory