Phenotypes Associated with This Genotype

Genotype
MGI:3803975

• Allelic Composition: Rag1^tm1Mom/Rag1^tm1Mom; Tg(Lck-Akt1*E40K)E-3Pnt/0
• Genetic Background: involves: 129S7/SvEvBrd * C3H/He * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased thymocyte number ( J:135903 )

• thymocyte numbers increase with age

increased double-positive T cell number ( J:135903 )

• 96% of thymocytes are double positive

• the presence of the transgene rescues the block of T cell development that occurs at DN3 in Rag1^tm1Mom homozygotes

hematopoietic system

increased thymocyte number ( J:135903 )

• thymocyte numbers increase with age

increased double-positive T cell number ( J:135903 )

• 96% of thymocytes are double positive

• the presence of the transgene rescues the block of T cell development that occurs at DN3 in Rag1^tm1Mom homozygotes

endocrine/exocrine glands

increased thymocyte number ( J:135903 )

• thymocyte numbers increase with age