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Phenotypes Associated with This Genotype
Genotype
MGI:3803975
Allelic
Composition		 Rag1tm1Mom/Rag1tm1Mom
Tg(Lck-Akt1*E40K)E-3Pnt/0
Genetic
Background		 involves: 129S7/SvEvBrd * C3H/He * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (56 available); any Rag1 mutation (132 available)
Tg(Lck-Akt1*E40K)E-3Pnt mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased thymocyte number ( J:135903 )
• thymocyte numbers increase with age
increased double-positive T cell number ( J:135903 )
• 96% of thymocytes are double positive
• the presence of the transgene rescues the block of T cell development that occurs at DN3 in Rag1tm1Mom homozygotes

hematopoietic system
increased thymocyte number ( J:135903 )
• thymocyte numbers increase with age
increased double-positive T cell number ( J:135903 )
• 96% of thymocytes are double positive
• the presence of the transgene rescues the block of T cell development that occurs at DN3 in Rag1tm1Mom homozygotes

endocrine/exocrine glands
increased thymocyte number ( J:135903 )
• thymocyte numbers increase with age

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory