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Phenotypes Associated with This Genotype
Genotype
MGI:3803967
Allelic
Composition		 Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt2tm1.1Mbb mutation (2 available); any Akt2 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:135903 )
N
• no abnormalities in T cell development are observed

homeostasis/metabolism
hyperglycemia ( J:160759 )
• about 25-30% increase in fasting glucose levels at 1 month of age
impaired glucose tolerance ( J:160759 )
• glucose intolerance
decreased liver triglyceride level ( J:160759 )
• 2-fold decrease in liver triglyceride levels

liver/biliary system
decreased liver triglyceride level ( J:160759 )
• 2-fold decrease in liver triglyceride levels

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory