Phenotypes Associated with This Genotype

Genotype
MGI:3803813

• Allelic Composition: Tg(Lck-Akt1*E40K)E-3Pnt/0
• Genetic Background: involves: C3H/He * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:73487 )

• about half of the mice are dead one year of age from thymic lymphomas

neoplasm

increased T cell derived lymphoma incidence ( J:73487 )

• most mice die from lymphoid neoplasms

• lymphomas contain clonal rearrangements in the T cell receptor genes lymphomas contain clonal rearrangements in the T cell receptor genes

immune system

decreased thymocyte number ( J:73487 )

• number of thymocytes is decreased by about 20% compared to wild-type mice despite the thymus having similar weight as in wild-type

• thymocyte cell size is significantly increased in these mice

enlarged spleen ( J:73487 )

• is often observed in necropsy due to lymphomas

hematopoietic system

decreased thymocyte number ( J:73487 )

• number of thymocytes is decreased by about 20% compared to wild-type mice despite the thymus having similar weight as in wild-type

• thymocyte cell size is significantly increased in these mice

enlarged spleen ( J:73487 )

• is often observed in necropsy due to lymphomas

cellular

abnormal cell cycle checkpoint function ( J:73487 )

• thymocyte cell size is significantly increased in these mice

• thymocytes express high levels of cyclin D2, D3,and E and promote progression through G1

endocrine/exocrine glands

decreased thymocyte number ( J:73487 )

• number of thymocytes is decreased by about 20% compared to wild-type mice despite the thymus having similar weight as in wild-type

• thymocyte cell size is significantly increased in these mice

increased T cell derived lymphoma incidence ( J:73487 )

• most mice die from lymphoid neoplasms

• lymphomas contain clonal rearrangements in the T cell receptor genes lymphomas contain clonal rearrangements in the T cell receptor genes

growth/size/body

enlarged spleen ( J:73487 )

• is often observed in necropsy due to lymphomas