mortality/aging
• about half of the mice are dead one year of age from thymic lymphomas
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neoplasm
• most mice die from lymphoid neoplasms
• lymphomas contain clonal rearrangements in the T cell receptor genes
lymphomas contain clonal rearrangements in the T cell receptor genes
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immune system
• number of thymocytes is decreased by about 20% compared to wild-type mice despite the thymus having similar weight as in wild-type
• thymocyte cell size is significantly increased in these mice
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• is often observed in necropsy due to lymphomas
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hematopoietic system
• number of thymocytes is decreased by about 20% compared to wild-type mice despite the thymus having similar weight as in wild-type
• thymocyte cell size is significantly increased in these mice
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• is often observed in necropsy due to lymphomas
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cellular
• thymocyte cell size is significantly increased in these mice
• thymocytes express high levels of cyclin D2, D3,and E and promote progression through G1
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endocrine/exocrine glands
• number of thymocytes is decreased by about 20% compared to wild-type mice despite the thymus having similar weight as in wild-type
• thymocyte cell size is significantly increased in these mice
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• most mice die from lymphoid neoplasms
• lymphomas contain clonal rearrangements in the T cell receptor genes
lymphomas contain clonal rearrangements in the T cell receptor genes
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growth/size/body
• is often observed in necropsy due to lymphomas
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