Phenotypes Associated with This Genotype

Genotype
MGI:3803812

• Allelic Composition: Tg(Lck-Akt1*)M-1Pnt/0
• Genetic Background: involves: C3H/He * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:73487 )

• about half of the mice are dead at 90 days of age from thymic lymphomas

• less than 20% of the mice live past 240 days

neoplasm

increased T cell derived lymphoma incidence ( J:73487 )

• most mice die of thymic lymphomas

• lymphomas contain clonal rearrangements in the T cell receptor genes

• all tumors are lymphoblastic lymphomas with variable expression of the CD4 and CD8 genes

immune system

decreased thymocyte number ( J:73487 )

• number of thymocytes is decreased by more than 20% compared to wild-type mice despite the thymus having similar weight as in wild-type

enlarged spleen ( J:73487 )

• is often observed in necropsy due to lymphomas

increased double-negative T cell number ( J:135903 )

• there is a five-fold increase in the percentage of double negative thymocytes found in the thymus

• double negative thymocytes progress rapidly through the DN3 to DN4 stage

increased single-positive T cell number ( J:135903 )

• the percentage of single positive thymocytes is increased in these mice

cellular

abnormal cell cycle checkpoint function ( J:73487 )

• thymocyte cell size is significantly increased in these mice

• thymocytes express high levels of cyclin D2, D3,and E and promote progression through G1

hematopoietic system

decreased thymocyte number ( J:73487 )

• number of thymocytes is decreased by more than 20% compared to wild-type mice despite the thymus having similar weight as in wild-type

enlarged spleen ( J:73487 )

• is often observed in necropsy due to lymphomas

increased double-negative T cell number ( J:135903 )

• there is a five-fold increase in the percentage of double negative thymocytes found in the thymus

• double negative thymocytes progress rapidly through the DN3 to DN4 stage

increased single-positive T cell number ( J:135903 )

• the percentage of single positive thymocytes is increased in these mice

endocrine/exocrine glands

decreased thymocyte number ( J:73487 )

• number of thymocytes is decreased by more than 20% compared to wild-type mice despite the thymus having similar weight as in wild-type

increased T cell derived lymphoma incidence ( J:73487 )

• most mice die of thymic lymphomas

• lymphomas contain clonal rearrangements in the T cell receptor genes

• all tumors are lymphoblastic lymphomas with variable expression of the CD4 and CD8 genes

growth/size/body

enlarged spleen ( J:73487 )

• is often observed in necropsy due to lymphomas