Phenotypes Associated with This Genotype

Genotype
MGI:3803709

• Allelic Composition: Shox2^tm1Acgg/Shox2^tm1Acgg
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:135454 )

• embryos die between E11.5 and E13.5

cardiovascular system

abnormal heart development ( J:135454 )

• the common atrium is slightly enlarged in E9.5 embryos

• venous valves are hypoplastic in E10.5 embryos in addition to an enlarged common atrium

• morphology of the developing heart changes dramatically between E10.5 and E11.5

• the ventricles are dislocated by E11.5

• the atria becomes severely dilated with the myocardial wall of the atria much thinner than in control embryos

• the venous valves are hypoplastic and in some cases absent at E11.5

abnormal sinus venosus morphology ( J:135454 )

• the venous valves are hypoplastic and in some cases absent at E11.5

pericardial edema ( J:135454 )

• E11.5 embryos frequently have pericardia edema

homeostasis/metabolism

pericardial edema ( J:135454 )

• E11.5 embryos frequently have pericardia edema