Phenotypes Associated with This Genotype

Genotype
MGI:3803670

• Allelic Composition: Wt1^tm1Mlh/Wt1^tm1Mlh
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:135449 )

• homozygotes are embryonic lethal

• 17% of embryos die by E12.5 and 71% of embryos die by E13.5

embryonic lethality during organogenesis, incomplete penetrance ( J:135449 )

• 17% of embryos die by E12.5

growth/size/body

decreased embryo size ( J:135449 )

• embryo size is reduced at E12.5 and E13.5 compared to age-matched control embryos

endocrine/exocrine glands

abnormal adrenal gland development ( J:135449 )

• adrenal primordia in E13.5 embryos are significantly smaller

agonadal ( J:135449 )

• gonads are absent in all E13.5 embryos

absent ovary ( J:135449 )

♀

absent testes ( J:135449 )

♂

embryo

decreased embryo size ( J:135449 )

• embryo size is reduced at E12.5 and E13.5 compared to age-matched control embryos

reproductive system

agonadal ( J:135449 )

• gonads are absent in all E13.5 embryos

absent ovary ( J:135449 )

♀

absent testes ( J:135449 )

♂

renal/urinary system

abnormal kidney development ( J:135449 )

• E13.5 embryos fail to develop a metanephros

absent metanephros ( J:135449 )

cardiovascular system

myocardium hypoplasia ( J:135449 )

abnormal heart development ( J:135449 )

• cardiac dysplasia is noted in all embryos at E13.5

• both ventricles have poorly developing compact and trabecular myocardium in the free walls

• atrial cavaties are dilated with thickened epicardium

• other cardiac abnormalities noted in E13.5 embryos are hypoplastic myocardium, heart shape abnormalities with rounded apex, and improper epicardium and mesocardial attachment

abnormal heart apex morphology ( J:135449 )

• rounded heart apex

abnormal heart shape ( J:135449 )

hemopericardium ( J:135449 )

• pericardial hemorrhaging in about half the embryos

liver/biliary system

abnormal liver development ( J:135449 )

• the livers of E12.5 and E13.5 embryos are hypoplastic and deficient in lobation

liver hypoplasia ( J:135449 )

muscle

myocardium hypoplasia ( J:135449 )

abnormal diaphragm development ( J:135449 )

• diaphragms are incompletely formed in all embryos at E12.5 with an increase in the dorsolateral gap

• E13.5 embyros have large openings between the pleural and peritoneal spaces

homeostasis/metabolism

hemopericardium ( J:135449 )

• pericardial hemorrhaging in about half the embryos