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Phenotypes Associated with This Genotype
Genotype
MGI:3803346
Allelic
Composition		 Ifih1tm1Aki/Ifih1tm1Aki
Ticam1tm1Aki/Ticam1tm1Aki
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifih1tm1Aki mutation (1 available); any Ifih1 mutation (43 available)
Ticam1tm1Aki mutation (0 available); any Ticam1 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal interferon level ( J:137522 )
• fail to produce interferon alpha in response to poly(I:C)
abnormal interleukin level ( J:137522 )
• fail to produce IL6 and IL12p40 in response to poly(I:C)

homeostasis/metabolism
abnormal interferon level ( J:137522 )
• fail to produce interferon alpha in response to poly(I:C)
abnormal interleukin level ( J:137522 )
• fail to produce IL6 and IL12p40 in response to poly(I:C)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory