Phenotypes Associated with This Genotype

Genotype
MGI:3803345

• Allelic Composition: Rigi^tm1Aki/Rigi^tm1Aki
• Genetic Background: involves: 129/Sv * C57BL/6 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Flaviviridae infection induced morbidity/mortality ( J:137522 )

• more susceptible to Japanese encephalitis virus and vesicular stomatitis virus induced lethality

• but susceptibility to encephalomyocarditis virus is similar to controls

decreased survivor rate ( J:137522 )

• Background Sensitivity: when heterozygotes on a mixed ICR background are crossed some homozygous mice survive to adulthood but the numbers are about half that of wild-type littermates

immune system

abnormal interferon level ( J:137522 )

• markedly decreased serum interferon alpha level following infection with Japanese encephalitis virus

increased susceptibility to Flaviviridae infection induced morbidity/mortality ( J:137522 )

• more susceptible to Japanese encephalitis virus and vesicular stomatitis virus induced lethality

• but susceptibility to encephalomyocarditis virus is similar to controls

homeostasis/metabolism

abnormal interferon level ( J:137522 )

• markedly decreased serum interferon alpha level following infection with Japanese encephalitis virus