Phenotypes Associated with This Genotype

Genotype
MGI:3803204

• Allelic Composition: Aire^tm1.1Doi/Aire^tm1.1Doi; Tg(Ins2-TFRC/OVA)296Wehi/0; Tg(TcraTcrb)425Cbn/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell differentiation ( J:135154 )

• negative selection of CD 4 T cells bearing the transgenic TCR is impaired as evidenced by only a slight reduction of clonotypic T cells occuring in the thymus and spleen

decreased CD4-positive, alpha-beta T cell number ( J:135154 )

• there is a slight reduction in the number of CD4 single positive thymocytes in the thymus compared to controls

hematopoietic system

abnormal T cell differentiation ( J:135154 )

• negative selection of CD 4 T cells bearing the transgenic TCR is impaired as evidenced by only a slight reduction of clonotypic T cells occuring in the thymus and spleen

decreased CD4-positive, alpha-beta T cell number ( J:135154 )

• there is a slight reduction in the number of CD4 single positive thymocytes in the thymus compared to controls