Phenotypes Associated with This Genotype

Genotype
MGI:3803202

• Allelic Composition: Tg(Ins2-TFRC/OVA)296Wehi/0; Tg(TcraTcrb)425Cbn/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased double-positive T cell number ( J:135154 )

• the percentage of double-positive T cells in the thymus is increased by 20 % compared to control mice

decreased CD4-positive, alpha-beta T cell number ( J:135154 )

• there is a 10 fold drop in the number of CD4 single positive thymocytes in the thymus compared to controls due to increased negative selection of T cell bearing the transgenic TCR

• the number of CD4 T cells in the periphery that express the gene segments associated with the transgenic TCR is reduced almost by half compared to mice carrying just the Tg(TcraTcrb)425Cbn OT-II transgene

hematopoietic system

increased double-positive T cell number ( J:135154 )

• the percentage of double-positive T cells in the thymus is increased by 20 % compared to control mice

decreased CD4-positive, alpha-beta T cell number ( J:135154 )

• there is a 10 fold drop in the number of CD4 single positive thymocytes in the thymus compared to controls due to increased negative selection of T cell bearing the transgenic TCR

• the number of CD4 T cells in the periphery that express the gene segments associated with the transgenic TCR is reduced almost by half compared to mice carrying just the Tg(TcraTcrb)425Cbn OT-II transgene