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Phenotypes Associated with This Genotype
Genotype
MGI:3803119
Allelic
Composition
Tg(Scgb1a1-Il17f,GFP)1Cdon/?
Genetic
Background
C57BL/6-Tg(Scgb1a1-Il17f,GFP)1Cdon
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Scgb1a1-Il17f,GFP)1Cdon mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice develop abnormal lung pathology starting at 5 months of age
• there is substantial peribronchial and perivascular infiltration of macrophages, B cells and CD4 T cells in the lungs
• in some mice, Charcot-Leyden like crystals are found in the airway

respiratory system
• mice develop abnormal lung pathology starting at 5 months of age
• there is substantial peribronchial and perivascular infiltration of macrophages, B cells and CD4 T cells in the lungs
• in some mice, Charcot-Leyden like crystals are found in the airway
• increased mucus production occurs in the lung in conjuction with lung inflammation


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory