Phenotypes Associated with This Genotype

Genotype
MGI:3803100

• Allelic Composition: En1^tm2(cre)Wrst/?; Gli3^tm1Alj/Gli3^tm1Alj; Smo^tm2Amc/Smo^tm2Amc
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:137136 )

N • isthmus generally normal

N • superior colliculus normal

N • inferior colliculus normal

abnormal rhombomere morphology ( J:137136 )

• some Purkinje cells in anterior isthmus region

• Purkinje projections into posterior isthmus region

• dorsal mesencephalon, isthmus, and r1 not distinct at E10.5 and E12.5

• isthmus flexure less prominent

• thickness of ventricular zone increased

enlarged cerebral aqueduct ( J:137136 )

• expanded mesencephalic ventricle at E10.5 and E12.5

abnormal tectum morphology ( J:137136 )

• misshapen

enlarged tectum ( J:137136 )

abnormal hindbrain morphology ( J:137136 )

abnormal cerebellum morphology ( J:137136 )

abnormal cerebellar foliation ( J:137136 )

• abnormal at E18.5

thin external granule cell layer ( J:137136 )

• external granule cell layer thinner at birth

small cerebellum ( J:137136 )

• at birth

embryo

abnormal rhombomere morphology ( J:137136 )

• some Purkinje cells in anterior isthmus region

• Purkinje projections into posterior isthmus region

• dorsal mesencephalon, isthmus, and r1 not distinct at E10.5 and E12.5

• isthmus flexure less prominent

• thickness of ventricular zone increased