Analysis Tools
behavior/neurological
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• following treatment with pilocarpine, mice exhibit a shorter latency to the first epileptiform discharge and first seizure episode compared to wild-type mice
• however, duration of seizure episodes was not different than in similarly treated wild-type mice
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• in a wire-hang and rotarod test
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• grip strength is impaired
• however, grip strength can be improved by prior injections of cholinesterase inhibitors
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• mice exhibit a deficit in social recognition memory compared to wild-type mice
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• mice are unable to maintain long periods of physical activities unlike wild-type mice
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nervous system
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• following treatment with pilocarpine, mice exhibit a shorter latency to the first epileptiform discharge and first seizure episode compared to wild-type mice
• however, duration of seizure episodes was not different than in similarly treated wild-type mice
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• steady-state depression of evoked endplate potential is greater than in wild-type mice
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• mice exhibit smaller and less frequent miniature endplate potentials than in wild-type mice
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• acetylcholine release is decreased compared to in wild-type mice
• acetylcholine levels in the brain are increased compared to in wild-type and heterozygous mice due to reduced release
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homeostasis/metabolism
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• mice are unable to maintain long periods of physical activities unlike wild-type mice
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