Phenotypes Associated with This Genotype

Genotype
MGI:3802986

• Allelic Composition: Adcy1^tm1Ito/Adcy1^tm1.1Ito; Tg(Emx1-cre)3Ito/0
• Genetic Background: B6.Cg-Adcy1^tm1Ito Adcy1^tm1.1Ito Tg(Emx1-cre)3Ito

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:137123 )

N • despite abnormal barrel cortex morphology, lesion-induced plasticity of the thalamocortical axonal pattern and synaptic release efficacy are normal

abnormal barrel cortex morphology ( J:137123 )

• while gross barrel patterning is normal, barrel wall formation is disrupted

• dendritic orientation of layer IV neurons in the barrel cortex is impaired and dendritic span is increased compared to in wild-type micedendritic orientation of layer IV neurons in the barrel cortex is impaired and dendritic span is increased compared to in wild-type mice

reduced long-term potentiation ( J:137123 )

• during thalamocorical synapse development

decreased miniature excitatory postsynaptic current amplitude ( J:137123 )

• AMPA receptor mini-excitatory postsynaptic currents of thalamocortical synapses are smaller than in wild-type mice